Consistently rapid, deep and durable reduction in serum TTR accompanied by evidence of disease stabilization or improvement after a one-time treatment of nex-z, supporting the hypothesis that greater TTR reduction may lead to a greater clinical benefit in ATTR amyloidosis Favorable trends consistently observed across multiple markers of cardiac disease progression at month 12 compared to baseline in an ATTR-CM population with a high proportion of advanced heart failure patientsConsistent trend observed to date in ATTRv-PN arm, with stability or improvement of neuropathy as measured by multiple clinical measures of disease progression compared to baselinePersistently deep levels of serum TTR…
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There are a few key trends to look for if we want to identify the next multi-bagger. In a perfect world, we’d like to see a company investing more capital into its business and ideally the returns earned from that capital are also increasing. If you see this, it typically means it’s a company with a great business model and plenty of profitable reinvestment opportunities. Speaking of which, we noticed some great changes in Coupang’s (NYSE:CPNG) returns on capital, so let’s have a look. For those that aren’t sure what ROCE is, it measures the amount of pre-tax profits a…
The closure of a large US-owned limestone quarry in Mexico has jolted investors and the world’s largest bilateral trade relationship, in a case seen as a thermometer for the political and legal climate under President Claudia Sheinbaum.The limestone quarry on Mexico’s Yucatán peninsula, which dates from the 1980s, was thrust into the spotlight by former president Andrés Manuel López Obrador. He shut down operations in 2022, then during his last week in office in September declared its land a national protected area, in effect preventing it from reopening. He accused the quarry of causing an environmental “catastrophe”.Alabama-based Vulcan Materials, which…
The recent volatility in key GLP-1 stocks has put the spotlight on the anxiety Wall Street has about the weight loss market. The market is huge — a potential $150 billion a year by the end of the decade — and any financial miss, or negative data of any kind, will trigger outsized sell-offs. This past week, for example, Amgen (AMGN) lost $12 billion in market value. Hims & Hers (HIMS) lost 10% in a single day in October when the FDA ended the shortage designation of Eli Lilly’s (LLY) drugs. (Its worst day on record was Nov. 14, down…
Image source: Getty Images Some people put a little bit of money into an ISA now and again, hoping they will end up with more than they contributed. For others, though, a Stocks and Shares ISA can be the path to becoming not just a millionaire, but multi-millionaire. With that objective, here the approach I would take if I had sufficient spare money. Choosing a Stocks and Shares ISA My first move would be to decide what Stocks and Shares ISA to choose. There are lots of options available. I think picking the one that suited my own financial circumstances…
The color of your car’s exhaust smoke can be a telling indicator of its overall health. Different smoke colors often signify specific issues within the engine or other components. For instance, white smoke can suggest a coolant leak, while blue smoke typically indicates that the engine is burning oil. Black smoke is often a sign of excess fuel being burned, and gray smoke can point to problems with the transmission or the PCV valve. By paying attention to the color of your exhaust smoke, you can diagnose potential problems early and take action to prevent further damage. Regular maintenance and…
MANILA (Reuters) -Philippine authorities issued an urgent appeal on Saturday for residents in low-lying areas and coastal towns to move to safety as super typhoon Man-Yi gained strength on its approach towards the country’s main Luzon island. Man-Yi, the sixth tropical cyclone to hit the Philippines in a month, intensified with maximum sustained winds reaching 195 kph (121 mph) and gusts up to 240 kph, according to state weather agency PAGASA. This prompted it to raise its storm alert to its highest level for the provinces of Catanduanes and Camarines Sur in the central Bicol region. Ariel Nepomuceno, head of…
Skipping routine car maintenance might seem like an easy way to save time and money, but it can lead to significant and costly problems in the long run. Regular maintenance tasks such as oil changes, tire rotations, and brake inspections are essential for keeping your vehicle in good working condition and preventing minor issues from becoming major headaches. Neglecting these tasks can result in increased repair costs, reduced fuel efficiency, decreased vehicle lifespan, and even safety risks. Additionally, failing to adhere to maintenance schedules can void your car’s warranty and lead to higher depreciation. Investing in regular maintenance ensures your…
The tech sector, once a powerhouse of growth and high-paying jobs, has seen a dramatic shift, with many leading firms cutting thousands of positions. Companies such as Microsoft Corporation (MSFT), Meta Platforms (META), Amazon.com (AMZN), and Alphabet Inc. (GOOGL) have scaled back their workforce to streamline operations amid a challenging economic environment. Salesforce, Inc. (CRM), the world’s leading provider of customer relationship management software, is no exception, implementing layoffs and cost-cutting measures to bolster financial efficiency. Yet, despite the shake-up, Salesforce appears better equipped than many peers to navigate this uncertain terrain, backed by a robust product lineup and a…
Image source: Getty Images What does it take to get into the stock market? Some people want to start buying shares but keep putting it off because they think it takes a lot of money. In fact, not only is it possible to get investing on a tight budget, but I think it has some advantages compared to waiting for a bigger pot before one gets going. One of them is that, hopefully, any beginners’ mistakes will be less financially painful. If I was in the shoes of a friend that had a spare fiver a day and wanted to…